What is the role of reirradiation in the management of locoregionally relapsed non small-cell lung cancer?

•Reirradiation is a treatment option for locoregionally recurrent NSCLC.•Evidence are actually limited and no analysis exists to guide its indication.•The current review explores the state of the art of reirradiation in this setting.•Reirradiation is feasible and can attain in selected patients long-term control.•Patients selection criteria and toxicity predictive factors were identified.