Isolated limb perfusion for soft tissue sarcoma: current practices and future directions. A survey of experts and a review of literature

•ILP may be an effective treatment for limb preservations in ESTS.•The combination of melphalan and TNFα is the standard drug regimen for sarcoma.•Limb preservation rates from 72 to 96%; overall response rates from 72 to 82.5%.•Innovating agents might allow for better patient selection and outcome.•Great variation in technique among centers that should be addressed.