A One-Pot Synthesis Of 2-Aminothiazoles Via The Coupling Of Ketones And Thiourea Using I-2/Dimethyl Sulfoxide As A Catalytic Oxidative System

A series of 2-aminothiazoles is prepared in moderate-to-good yields by the direct coupling of ketones and thiourea using I-2/dimethyl sulfoxide as a catalytic oxidative system. This method avoids the preparation of lachrymatory and toxic alpha-haloketones and the use of an acid-binding agent, thus providing a more convenient approach to 2-aminothiazoles compared to the Hantzsch reaction.