Advances in Understanding CREB Signaling-Mediated Regulation of the Pathogenesis and Progression of Epilepsy

•CREB is a key regulator of synapse remodeling in dendritic spine growth and mossy fiber sprouting.•Seizure enhances the expression and phosphorylation of CREB.•A CREB-mediated molecular regulatory network is involved in epileptogenesis.•CREB signaling is a target for the development of first-line antiepileptic drugs.•CREB may be an important biomarker for clinical screening, diagnosis and prognosis of epilepsy.