Numerical study of the formation and drying kinetics of a capillary bridge of trehalose solution between two parallel hydrophilic fibres

Chemical Engineering Science(2020)

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摘要
•Stability of capillary bridging during drying can be modelled with simplifications.•Marangoni flow is essential to maintain capillary bridging during drying.•Trehalose at sufficient high concentrations can result in dried capillary bridging.•Capillary Bridge Criterion can be used to predict stability of capillary bridge.•Modelling can be used to guide the formulation and drying of biotherapeutics.
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关键词
Matrix assisted room temperature (MART) drying,Capillary bridge,Evaporation,Marangoni flow,Capillary bridge criterion,Virtification
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