Validity of the McDonald criteria in predicting second events in multiple sclerosis.

1This is the first meta-analysis on McDonald criteria and make comparison between 2010 and 2017 criteria.2We solve the current negotiation on diagnostic performance between 2010 and 2017 criteria, we conclude 2017 criteria to be better performed with increased sensitivity but decreased specificity.3We further detect reasons for reduced specificity, find DMT to be accountable and give recommendations to future researches.4We also find McDonald criteria have better performance in children rather than adults.