_2 tumor by ultrasound mediated microbubble disruption

：Objective To investigatethe feasibility of VX_2 tumor growth inhibition by using ultrasound mediated microbubbledisruption.Methods Twenty-one New Zealand white rabbits bearing subcutaneous VX_2tumorwere randomly divided into 3 groups for the impact factors including microbubbles(MB)andultrasound(US).Pulsed focused ultrasound was delivered directly to the tumor surface forten minutes following intravenous infusion of microbubbles in theexperimental(US+MB)group.The two control groups were applied with only saline injectionand sham US exposure.The procedure was repeated every 72 hours until the 30th day.Contrastand grey scale ultrasonography were acquired after every treatment to get the tumorperfusion and measurement.Results The diameters were sized every 72h in a course of 30days.The average maxium diameter of the US+MB,US,and SHAM groups increased from(1.1±0.1)cm,(1.2±0.1)cm,(1.2±0.1)cmto(2.1±0.5)cm,(3.0±0.9)cm,(3.4±0.7)cm,respectively.The maximal diameter of the US+MBgroup was significantly smaller than those of the two control groups.Conclusions The VX_2tumor growth can be inhibited by ultrasound mediated microbubbte disruption effects.