Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing.

Irene A. Stafford,Fernando H. Centeno,Mayar Al Mohajer,George Parkerson,Laila Woc-Colburn, Angelica Janice Burgos-Lee,Martha Rac,James Dunn,Kenneth Muldrew

Case reports in obstetrics and gynecology（2020）

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摘要

Flea-borne (murine) typhus is caused by . Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic.

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