The changes of Thl7 and regulatory T cells in the process of anti-tuberculosis treatment of tuberculo-sis patients

Objective To observe the Thl7 and regulatory T cells（Tr） equilibrium state as well as their changes of tuberculosis patients in six-month＇s anti-Tuberculosis treatment. Methods Select thirty- two tuberculosis patients received anti-Tuberculosis treatment while thirty-two healthy Volunteers as controls. Flow cytometry was used to analyze Thl7 and Tr cells in venous blood at the time of pre-therapy, 3th, 6th month. Results The ratio of Thl7 cells in CIM cells in tuberculosis patients and volunteers were （ 1.10±0.39）%, （2.50±1.03）%, （3.90±1.34）%, （4.50±1.52）%, respectively; the ratio of Tr cells were （9.17±3.26）%, （6.85±2.73）%, （5.46±1.69）%, （4.35±0.86）%, respectively. Conclusion Tuberculosis could make Thl7 cells and Tr cells lost their balance, but the immune equilibrium state may grad- ually recover after anti-tuberculosis. The change of the amount of immune cells was likely to be the reference indexes to observe the progress of tuberculosis and the treatment effect of anti-tuberculosis.\r\n\r\nKey words: \r\nTuberculosis;  Thl7 cell;  Regulatory T cell（Tr） ;  Anti-tuberculosis