Clinical Conundrums: Developing A Strategy For Discerning Tp53-Associated Chip And Coherent Clinical Care.

Jeffrey N. Weitzel,Judy Ellen Garber,Danielle Castillo,Sharon Sand,Rosa Mejia,Aleck Cervantes,Samantha Stokes,Janet Mokhnatkin, Kar Wing Kevin Tsang,Jinhui Wang,Xiwei Wu,Josef Herzog,Bita Nehoray,Thomas Paul Slavin

JOURNAL OF CLINICAL ONCOLOGY（2020）

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摘要

1514Background: Germline TP53 mutations are associated with Li-Fraumeni syndrome (LFS). However, approximately 20% of commercial laboratory multigene panel test (MGPT)-detected pathogenic TP53 vari...

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