The diagnosis and prognosis of primary duodenal tumors

Objective\r\nTo evaluate the diagnostic procedures and treatment choice of primary malignant tumor of the duodenum.\r\n\r\n\r\nMethods\r\nThe clinical data of 170 cases with primary malignant tumor of the duodenum at Peking University People′s Hospital from 1996 to 2015 were analyzed retrospectively.\r\n\r\n\r\nResults\r\nTumors located in the first, second, third and fourth parts in 14 cases (8.2%), 144 cases (84.7%), 9 cases (5.3%), and 3 cases (1.8%)respectively, and among them, tumors within papillary area accounted for 62.4% (106 cases). The main clinical presentations included jaundice, upper abdominal pain, abdominal distention, nausea and vomiting. Among the 170 cases, 125 cases obtained accurate tumor stages, with 34 cases on stage Ⅰ(27.2%), 45 cases on stage Ⅱ(36.0%), 30 cases on stage Ⅲ(24.0%), 16 cases on stage Ⅳ(12.8%). The accuracy rate of ultrasound and CT in preoperative diagnosis was 27.6%, and 72.3% respectively. The pathological type of 144 cases(84.7%) was adenocarcinoma. The postoperative 1-, 3-and 5-year survival rate was 69.1%, 48.6%and 33.9%.\r\n\r\n\r\nConclusions\r\nMost primary malignant duodenal tumors are located in papillary region, necessitating radical pancreaticoduodenecomy, early diagnosis remains the key for longterm survival.\r\n\r\n\r\nKey words: \r\nDuodenal neoplasms; Adenocarcinoma; Pancreaticoduodenectomy