Inhibition of Capsular Contracture of Poly (Dimethyl Siloxane) Medical Implants by Surface Modification with Itaconic Acid Conjugated Gelatin

Mallinath S. Birajdar,Byung Hwi Kim,Chanutchamon Sutthiwanjampa,Shin Hyuk Kang,Chan Yeong Heo,Hansoo Park

Journal of Industrial and Engineering Chemistry（2020）

引用 13|浏览5

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摘要

•PDMS surfaces conjugated with itaconic acid±gelatin reduced protein adsorption•Modified PDMS surfaces resulted in lower inflammation and in vivo capsule thickness•Fewer myofibroblasts and fibroblasts grew on the functionalized surfaces•PDMS surface functionalization for implants may help prevent capsular contracture

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关键词

Poly (dimethylsiloxane),Itaconic acid,IA-GT polymer,Surface conjugation,Anti-fibrosis property.

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