Collagen Neo-Epitope Ratios Are Associated With Significant Weight Loss, And Improvement Of Non-Invasive Test (Nit) In Patients With Non-Alcoholic Steatohepatitis (Nash)

well as in those with advanced fibrosis compared to those with stages £2 (263±20 vs. 200±7 ng/ml, p<0.001).However, VCAM-1 only showed a significant difference between advanced fibrosis and stages £2 (986±54 vs. 836±23 ng/ml, p=0.008), but not when NASH was compared to NAFL.More interestingly, as can be observed in Figure 1, increasing ICAM-1 levels were significantly associated with worsening of each of the histological parameters assessed in NASH.This robust association was not observed when the same analysis was repeated for VCAM-1.Conclusions Plasma ICAM-1 was strongly associated with histological severity of liver disease in NAFLD.This finding suggests that endothelial cell activation may play an important role in the development and progression of liver disease in NAFLD.Future in vitro studies will need to address the pathophysiologic role of this association.In the meantime, this molecule should be taken into account when developing potential noninvasive biomarkers for NASH and/or advanced fibrosis.