Su1957 ELDERLY-ONSET INFLAMMATORY BOWEL DISEASE IS ASSOCIATED WITH HIGHER RISKS OF INFECTIONS, CANCERS AND HOSPITALIZATION: RESULTS FROM A TERRITORY-WIDE HONG KONG IBD REGISTRY

Background:Incidence of elderly-onset inflammatory bowel disease (IBD), defined as age ‡ 60 at diagnosis, is increasing rapidly worldwide.We aimed to compare the clinical characteristics and natural history of elderly onset IBD patients to non-elderly onset IBDpatients.Methods: Patients with a confirmed diagnosis of IBD from 1981 to 2016 were identified from a territory wide Hong Kong IBD registry involving 13 hospitals.Demographics, comorbidities, clinical features and outcomes of elderly-onset IBD patients were compared to non-elderly onset IBD patients.Results: Total 2413 patients were identified, of whom 270 (11.2%) had elderly-onset IBD during 21805 person-years follow-up.Median follow-up duration was 111 months (Interquartile range [IQR]: 68-165 months).The ratio of ulcerative colitis (UC): Crohn's disease (CD) was higher in elderly-onset IBD than non-elderly onset IBD patients.(3.82:1 vs. 1.39:1; p<0.001).Elderly-onset Crohn's disease (CD) had less perianal involvement (5.4% vs. 25.4%;p