The Effect of Antibiotics in Preventing Hospitalisations in United Kingdom Children with Down's Syndrome

Purpose: Children with Down\u0027s Syndrome (DS) have increased rates of consultations and hospitalisations due to respiratory tract infections (RTIs) compared to children without DS. Despite this, few studies have assessed interventions to prevent or treat RTIs in this at-risk population. This restrospective cohort study aims to estimate the risk of hospitalisation following a General Practitioner (GP) consultation for an RTI and the effect of antibiotics in reducing this risk. Methods: Children aged 0-18 with and without DS were followed through primary and secondary healthcare records using the CALIBER programme. We …