T149. CARDIOVASCULAR RISK AND VASCULAR AGE IN ADULTS WITH SCHIZOPHRENIA COMPARED TO A HEALTHY POPULATION: DATA FROM CORTEX-SP STUDY

Abstract Background Cardiovascular disease (CVD) is the most common cause of death in people with schizophrenia (SP). The European guidelines on CVD prevention recommend that people with high levels of individual risk factors should automatically have all their risk factors actively managed. It is suggested that CVD risk in SP should be assessed by general risk charts and to include specific relative risk chart for people with severe mental illnesses. Therefore, the purpose of the present study was to estimate CVD risk and vascular age in adults with SP and compared them with a healthy sample. Methods A total of 85 participants with SP (16.2% women, 42.1±10.0 yr old) were compared with 30 HEALTHY participants (60.0% women, 40.0±9.0 yr old). CVD risk was calculated using Systematic Coronary Risk Estimation (SCORE), Framingham Heart Score-Cardiovascular Disease (FRS-CVD), relative risk SCORE and vascular age. Likewise, the variables assessed to calculate the risk charts were age, body mass index, smoking percentage, systolic blood pressure (SBP) through ambulatory blood pressure monitoring during 24 hours and through a fasting biochemical profile, high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC). Results All HEALTHY variables were in normal values. Sample with SP showed overweight (body mass index=27.1±6.1 kg∙m-2) and higher (P<0.001) smoking percentage than HEALTHY (69.8% vs. 16.1%). Both groups presented normotensive SBP values (SP=115±15 mmHg, HEALTHY=113±10 mmHg). Concerning cholesterol profile, SP showed lower to optimal values in HDL-C (39.0±12.0 mg/dL), yet both were in optimal TC levels (SP=189.7±44 mg/dL, HEALTHY=183.6±35.1 mg/dL). Considering SCORE, both groups were in low risk values with higher (P<0.001) values in SP (0.6±1.0 vs. 0.1±0.4). However, according to relative risk SCORE and FRS-CVD, SP showed medium risk (2.0±1.0; 6.7±12.3), and HEALTHY low (1.0±0.4; 2.6±2.8) risk, respectively. Vascular age was higher (P<0.001) in SP than HEALTHY (48.0±26.0 vs. 36.0±24.0 yr). Discussion Patients suffering from SP compared to HEALTHY showed higher CVD risk and vascular age. These results strongly suggest the promotion of a healthy lifestyle behavior in order to optimize risk factors.