Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis

Philip G. Conaghan,Michael A. Bowes,Sarah R. Kingsbury,Alan Brett,Gwenael Guillard,Biljana Rizoska,Niclas Sjögren,Philippa Graham,Åsa Jansson, Cecilia Wadell,Richard Bethell,John Öhd

Annals of Internal Medicine（2019）

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摘要

Preclinical studies suggest that MIV-711, a selective and reversible cathepsin K inhibitor, has beneficial effects on bone and cartilage. This phase 2a randomized controlled trial examined the effi...

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