STAT3: Versatile Functions in Non-Small Cell Lung Cancer.
CANCERS(2020)
摘要
Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in non-small cell lung cancer (NSCLC) patient samples/cell lines and STAT3 inhibition in NSCLC cell lines markedly impairs their survival. STAT3 also plays a pivotal role in driving tumor-promoting inflammation and evasion of anti-tumor immunity. Consequently, targeting STAT3 either directly or by inhibition of upstream regulators such as Interleukin-6 (IL-6) or Janus kinase 1/2 (JAK1/2) is considered as a promising treatment strategy for the management of NSCLC. In contrast, some studies also report STAT3 being a tumor suppressor in a variety of solid malignancies, including lung cancer. Here, we provide a concise overview of STAT3's versatile roles in NSCLC and discuss the yins and yangs of STAT3 targeting therapies.
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关键词
signal transducer and activator of transcription (STAT),Janus kinase (JAK),cytokines,interleukin (IL),non-small cell lung cancer (NSCLC),lung adenocarcinoma (AC),Kirsten rat sarcoma viral proto-oncogene (K-RAS),epidermal growth factor receptor (EGFR),tumor microenvironment (TME),tumor-promoting inflammation,anti-tumor immunity,clinical trials
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