Electrochemical characterization of coatings for local prevention of Candida infections on titanium-based biomaterials
Progress in Organic Coatings(2020)
摘要
•Sol-gel coatings loaded with fluconazole or anidulafungin were prepared.•The mechanism of local release of the antifungal is the coating degradation.•The coating degradation was studied by EIS and was influenced by its cross-linking.•The cross-linking depends on the concentration and molecular weight of antifungals.•Coatings loaded with anidulafungin showed non-cytotoxicity and antifungal effectiveness.
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关键词
Fungal prosthetic joint infection,Antifungal coating/ powder metallurgy titanium substrate,Antifungal local release,Sol-gel technology,EIS,In-vitro tests
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