Dark-field illumination in conjunction with confocal Raman spectroscopy for real-time noninvasive aqueous humor investigation
OPTICAL ENGINEERING(2020)
摘要
To obtain a real-time noninvasive analysis of the content of the aqueous humor (AH) in the eye, a confocal dark-field ophthalmic probe was designed and optimized by ray-tracing software. The confocal technique allows Raman spectrometric sampling of the AH with suppressing signals from the surrounding tissues. Dark-field illumination prevents the excitation light to reach the vulnerable retinal tissue directly. In order to evaluate the optical performance and safety of this method, a functional prototyped eye contact probe has been designed and tested on ex vivo rabbit eyes. (C) 2020 Society of Photo-Optical Instrumentation Engineers (SPIE)
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关键词
Raman spectroscopy,eye,aqueous humor,confocal microscopy,dark-field illumination
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