Does the addition of cannabidiol to conventional antiepileptic drug treatment reduce seizure frequency in dogs with epilepsy

#### Bottom line\n\nBonzo is a five-year-old Staffordshire bull terrier that has been treated for idiopathic epilepsy with phenobarbitone and potassium bromide (KBr) – you had previously tried levetiracetam, but the combination of phenobarbital and KBr was more efficacious in Bonzo’s case. However, he is still having more than two seizures a month, despite achieving therapeutic levels of the drugs in his blood. You and the owner are keen to improve this if possible.\n\nThere has recently been much news coverage regarding the use of cannabidiol (CBD) to treat epilepsy in people. So, you wonder if introducing CBD alongside the current treatment regimen would reduce the frequency of Bonzo’s seizures.\n\nIn \\[dogs with idiopathic epilepsy] does [cannabidiol in combination with current treatment compared with placebo plus current treatment\\] \\[decrease seizure frequency\\]?\n\nThe search strategy can be viewed at https://bestbetsforvets.org/bet/568, and it is also available as a supplement to this article …