Upregulation Of Glutaminase 2 And Neutrophil Cytosolic Factor 2 Associates With The Poor Prognosis Of Glioblastoma

Background: This study aimed to identify glioblastoma prognosis-associated genes with potential diagnosis or prognosis values using integrated bioinformatics analysis. Results: In total, 1831 differentially expressed genes (DEGs) between the glioblastoma and control samples were identified and were clustered into seven Weighed gene co-expression network analysis (WGCNA) modules. These DEGs were associated with different functional categories and pathways. Nine prognosis-associated DEGs (including glutaminase 2, GLS2 and neutrophil cytosolic factor 2, NCF2) were identified, and the higher expression levels of GLS2 and NCF2 genes were associated with the poor prognosis of glioblastoma in 'The Cancer Genome Atlas' cohort and a clinical cohort. Conclusion: These results showed that the two genes play novel roles in the etiological and development of glioblastoma.