Antileishmanial activity of cordiaquinone E towards Leishmania (Leishmania) amazonensis

Raiza Raianne Luz Rodrigues,Thaís Amanda Lima Nunes,Alyne Rodrigues de Araújo,José Delano Barreto Marinho Filho,Marcos Vinícius da Silva,Fernando Aécio de Amorim Carvalho,Otília Deusdenia Loiola Pessoa, Hozana Patrícia Silva Freitas,Klinger Antonio da Franca Rodrigues,Ana Jérsia Araújo

International Immunopharmacology（2021）

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摘要

•Cordiaquinone E showed antileishmanial activity in vitro to L. amazonensis;•Cordiaquinone E exhibited selectivity indexes (SI) greater than reference drugs;•Cordiaquinone E induced apoptosis in promastigotes forms;•Cordiaquinone E reduced the infection index of macrophages by L. amazonensis;•Cordiaquinone E increased TNF-α, IL-12, NO and ROS production and reduced IL-10 levels in macrophages infected.

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关键词

Cordiaquinone E,Leishmania amazonensis,Apoptosis,Cytokines

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