The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice

Ri-Feng Gao,Xiao Li,Hai-Yan Xiang,Heng Yang,Chun-Yu Lv,Xiao-Lei Sun, Hong-Zhang Chen,Yang Gao,Jue-Sheng Yang,Wei Luo,Yi-Qing Yang,Yan-Hua Tang

International Immunopharmacology（2021）

引用 49|浏览17

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摘要

•Oridonin, as well as MCC950 and CY-09, inhibits the NLRP3 inflammasome response.•Oridonin, found in traditional Chinese medicine, shows anti-inflammatory property in mice MI model.•Oridonin treatment reduces myocardial fibrosis and preserves cardiac function after MI.

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关键词

Myocardial infarction,Oridonin,NLRP3 inhibitor,Myocardial fibrosis,Cardiac remodeling

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