Optical porosimetry by gas in scattering media absorption spectroscopy (GASMAS) applied to roller compaction ribbons

Jonas Johansson,Anders Sparén, Håkan Wikström,Pirjo Tajarobi, Roland Koch, Patrik Lundin, Anders Långberg, Mikael Sebesta,Märta Lewander Xu

International Journal of Pharmaceutics(2021)

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摘要
Currently, there is a need for new technology for in-line or fast at-line assessment of solid material porosity. One specific gap is a fast technology to be used in connection to roller compaction (RC) manufacturing, where the porosity of the RC ribbons is critical to the manufacturing of tablets of the right tensile strength and disintegration properties.
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关键词
Roller compaction,Ribbon porosity,GASMAS,Time-of-flight,Optical porosity,Material analysis
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