Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway

Yuan Liang,Tiehua Zhang,Li Ren,Siyuan Jing,Zhuolin Li,Peng Zuo,Tiezhu Li,Yongjun Wang,Jie Zhang,Zhengyi Wei

Environmental Toxicology and Pharmacology（2021）

引用 23|浏览17

暂无评分

摘要

•Cucurbitacin IIb (CuIIb) exhibited the proliferation inhibitory activity in A549 cells.•CuIIb induced apoptosis via STAT3 pathway.•CuIIb suppressed the cell cycle and resulted G2/M phase cell cycle arrest.•Leu694 and Met769 are key amino acids for EGFR-CuIIb binding.•CuIIb inhibited the kinase activity of EGFR and may serve as a potential EGFR TKI.

查看译文

关键词

Cucurbitacin IIb (CuIIb),Epidermal growth factor receptor (EGFR),Tyrosine kinase inhibitor (TKI),Apoptosis,Cell cycle arrest,Binding mode

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要