Fluorescent Imaging Of Cytoplasmic Nucleolin In Live Cells By A Functionalized-Engineered Aptamer

Monitoring of over-expressed nucleolin in the cytoplasm facilitates early cancer diagnosis. Herein, we present a novel biosensing nanoscaffold based on anti-nucleolin aptamers and polymer-grafted graphene oxides for the fluorescent imaging of nucleolin in the cell cytoplasm, which can distinguish cancer cells from normal cells.