Widespread Traces Of Lytic Kaposi Sarcoma-Associated Herpesvirus In Primary Effusion Lymphoma At Single-Cell Resolution

Nicole C Rondeau,Michael O Finlayson,Jj L Miranda

MICROBIOLOGY RESOURCE ANNOUNCEMENTS（2020）

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摘要

Cancer cells of primary effusion lymphoma (PEL) often contain both Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). We measured the interplay of human, KSHV, and EBV transcription in a cell culture model of PEL using single-cell RNA sequencing. The data detect widespread trace expression of lytic KSHV genes.

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