Disordered autonomic function during exposure to moderate heat or exercise in a mouse model of Dravet syndrome

•Body temperature, heart rate, and breathing rate was studied in Dravet syndrome mice exposed to moderate heat or exercise stress.•When exposed to moderate heat stress, these mice failed to maintain temperature homeostasis.•During exercise, they exhibited a delayed parasympathetic withdrawal on electrocardiogram.•During recovery from exercise, they exhibited an excessive vagal response.•Uncovered novel autonomic disturbances may lead to effective approaches against seizures or SUDEP in Dravet syndrome.