Tumor-infiltrating CD8+ T cells in ALK-positive lung cancer are functionally impaired despite the absence of PD-L1 on tumor cells

Chenxi Zeng,Yi Gao,Jing Xiong,Jiawei Lu,Jianjian Yang,Xue Wang,Yixin Cai,Lequn Li,Xiangning Fu

Lung Cancer（2020）

引用 9|浏览20

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摘要

•Membrane PD-L1 expression was rarely observed in the presence of ALK rearrangements.•Tumor bed infiltration CD8 + T cell more frequent in tumors with ALK mutations.•CD8+ T cells infiltrating ALK+ tumors were unable to express IFNG.

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关键词

ALK-positive lung adenocarcinoma,Tumor-Infiltrating CD8+ T cells,IFNG,PD-L1,PD-1

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