The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice

Fabienne Rajas,Renaud Dentin, Alexane Cannella,Marine Silva,Margaux Raffin,Françoise Levavasseur,Amandine Gautier-Stein,Catherine Postic,Gilles Mithieux

Molecular Metabolism（2021）

引用 11|浏览15

暂无评分

摘要

•Hepatic deletion of both ChREBP and glucose-6 phosphatase collapses liver lipids.•Double deletion leads to excessive glycogen storage and a liver swollen with water.•Hepatic deletion of both ChREBP and glucose-6 phosphatase leads to death.•Glucose-6 phosphate homeostasis in hepatocytes is a vital function.

查看译文

关键词

Glucose production,Glucose-6 phosphate,Glycaemia,Glycogen storage disease type 1,Non-alcoholic fatty liver disease,Type 2 diabetes

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要