Factors affecting tumor responders and predictive biomarkers of toxicities in cancer patients treated with immune checkpoint inhibitors

Liqin Yao,Gang Jia,Lingeng Lu, Ying Bao,Wenxue Ma

International Immunopharmacology（2020）

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摘要

•Factors influencing tumor responders treated with ICIs.•Predictive biomarkers of irAEs.•New potential mechanisms of resistance to ICI therapy.

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关键词

Immune checkpoint inhibitor (ICI),Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4),Programmed cell death-1 (PD-1),Programmed death-ligand 1 (PD-L1),Immune-related adverse effects (irAEs)

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