Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain

•Three different cell types were tested for the effect upon PS nanoplastic exposure.•PS nanoplastic exposure reduced the viability of mixed neuronal cells.•Cells uptake PS nanoplastics into the cytoplasm for intracellular accumulation.•Intracellular uptake of PS nanoplastics occurs in a concentration-dependent manner.•Cellular vulnerability to accumulated PS nanoplastics depends on cell types.