Evidence that knock down of GSK-3β in Chronic Myelogenous Leukemia cells augments IFN-γ-induced apoptosis

Melissa R Kauffman,Saeed Nazemidashtarjandi,Davoud Ghazanfari,Abigail E Allen,Nathan M Reynolds,Ahmed Faik,Monica M Burdick,Kelly D McCall,Douglas J Goetz

Leukemia Research（2020）

引用 4|浏览16

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摘要

•Role of IFN-γ in apoptosis of Chronic Myelogenous/Myeloid Leukemia (CML) is unclear.•Glycogen synthase kinase–3 (GSK-3) has been implicated in cell death and survival.•IFN-γ induces modest apoptosis in a CML cell line.•CML cells in which GSK-3β is knocked down exhibited enhanced IFN-γ induced apoptosis.•Suggests GSK-3β protects against IFN-γ induced apoptosis of CML cells.

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关键词

Interferon,Glycogen synthase kinase-3,Leukemia,Apoptosis,BCR-ABL,Philadelphia chromosome

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