The Saccharomyces Cerevisiae Abc Subfamily D Transporter Pxa1/Pxa2p Co-Imports Coash Into The Peroxisome
FEBS LETTERS(2021)
摘要
ATP-binding cassette (ABC) subfamily D transporters are important for the uptake of fatty acids and other beta-oxidation substrates into peroxisomes. Genetic and biochemical evidence indicates that the transporters accept fatty acyl-coenzyme A that is cleaved during the transport cycle and then re-esterified in the peroxisomal lumen. However, it is not known whether free coenzyme A (CoA) is released inside or outside the peroxisome. Here we have used Saccharomyces cerevisiae and isolated peroxisomes to demonstrate that free CoA is released in the peroxisomal lumen. Thus, ABC subfamily D transporter provide an import pathway for free CoA that controls peroxisomal CoA homeostasis and tunes metabolism according to the cell's demands.
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关键词
ABC transporter, acyl‐, CoA, coenzyme A, coenzyme homeostasis, peroxisome, thioesterase
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