Canarimoic acid: new tirucallane triterpene with antisalmonellal activity from the stem bark of Canarium schweinfurthii Engl.
Natural Product Research(2022)
摘要
One new tirucallane triterpene named as canarimoic acid (1), and three known analogues: 3β-hydroxytirucalla-8,24-dien-21-oic acid (2), 3α-acetyltirucalla-8,24-diene-21oic acid (3) and 3-oxotirucalla-8,24-dien-21-oic (4) were isolated from the hydro-ethanolic crude extract of Canarium schweinfurthii. Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound 3 was the most active (MIC =16 µg/mL) against Salmonella Typhi and Salmonella Typhimurium followed by compound 1 (MIC= 32 µg/mL) against Salmonella Typhi and Salmonella Enteritidis.
更多查看译文
关键词
Canarium schweinfurthii,tirucallane triterpene,canarimoic acid,antisalmonellal activity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要