A Hepatocyte-Targeting Fluorescent Probe For Imaging Isoniazid-Induced Hydrazine In Hepg2 Cells And Zebrafish

Zhenbo Guo,Mei Wang,Xueyan Li,Xu Jia,Xiaoli Wang,Pingzhu Zhang,Chao Wei,Xiaoliu Li

CHEMICAL COMMUNICATIONS（2020）

引用 22|浏览7

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摘要

A hepatocyte-targeting fluorescent N2H4 probe, GHP, was first designed and synthesized employing N-acetylgalactosamine (GalNAc) as the hepatocyte-targeting group and 3-nitrophthalimide as the recognition moiety. The probe can be used to selectively image N2H4 produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish in situ.

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