A Novel Small Molecule Targets NKCC1 To Restore Synaptic Inhibition
TRENDS IN PHARMACOLOGICAL SCIENCES(2020)
摘要
Finely tuned excitation-inhibition balance is essential for proper brain function, and loss of balance resulting from reduced synaptic inhibition is associated with neurological disorders. Savardi and colleagues have discovered a novel inhibitor of a cation-chloride transporter that is required for synaptic inhibition, and which restores behaviors associated with Down syndrome (DS) and autism spectrum disorder (ASD).
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关键词
Down syndrome,NKCC1,autism,excitation–inhibition balance,in silico, drug discovery
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