Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children

•SCN2A rs2304016 AG genotype more prevalent in the VPA-resistant group in Chinese children with epilepsy.•In subgroup of focal seizure, SCN1A rs2298771 AG carriers showed lower incidence of VPA resistance than AA carriers.•SCN2A rs2304016 and SCN1A rs2298771 polymorphisms might be associated with the VPA response in epileptic children.