Bi-paratopic and Multivalent VH Domains Block ACE2 Binding and Neutralize SARS-CoV-2

Colton J. Bracken,Shion A. Lim,Paige Solomon,Nicholas J. Rettko,Duy P. Nguyen,Beth Shoshana Zha,Kaitlin Schaefer,James R. Byrnes,Jie Zhou,Irene Lui,Jia Liu,Katarina Pance, Caleigh M. Azumaya Jr.,Xin X. Zhou,Kevin K. Leung,James A. Wells

Nature Chemical Biology（2020）

Cited 78|Views55

Key words

Biologics,Infectious diseases,Protein design,SARS-CoV-2,Structural biology,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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