Advanced rules of relays
NATURE CHEMICAL BIOLOGY（2020）
摘要
Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.
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关键词
Enzyme mechanisms,Molecular neuroscience,Post-translational modifications,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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