Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women?

The Journal of Steroid Biochemistry and Molecular Biology(2021)

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摘要
•PCOS women could be more exposed to SARS-CoV-2 infection.•Hyperandrogenic PCOS women activity of Androgen Receptor is very high, and this would lead to a greater transcription of the TMPRSS2 gene.•Insulin resistance and uncontrolled glycaemia were reported as significant predictors of severity and deaths in patients infected with viruses.•Obesity of PCOS women could contribute to both diabetic and cardiovascular risk of COVID-19.•It could be hypothesized that VDD could take part to the link between obesity, PCOS and increased complications and mortality due to COVID-19.•PCOS women had a dysbiotic gut mirobiota that is a common feature underlying health problem associated with inflammation and other disorders.
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关键词
ACE2,AR,AT,IL,IR,IRS,PCOS,RAS,SARS-CoV-2,T2DM,VDD,VDR
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