Extinction Training after Cocaine Self-Administration Influences the Epigenetic and Genetic Machinery Responsible for Glutamatergic Transporter Gene Expression in Male Rat Brain

•Three-day extinction training reduced GLT-1 gene expression in the prefrontal cortex.•Decreased NFKB2 and PAX6 gene expression reduced GLT-1 gene in the prefrontal cortex.•Short-term extinction training reduced GLT-1 gene expression in the dorsal striatum.•Striatal higher levels of miR-543-3p and miR-342-3p decreased GLT-1 gene expression.•Three-day extinction training reduced xCT in the prefrontal cortex and dorsal striatum.