Triptolide attenuates renal damage by limiting inflammatory responses in DOCA-salt hypertension

•Triptolide (TP) had no effects on blood pressure in salt-sensitive hypertension.•The protective effects of TP on renal injury were found in salt-sensitive hypertension.•The protective effects of TP were associated with inhibition of inflammation.•TP suppressed inflammatory responses possibly via inhibition of NF-κB activity.