The effect of genetic variations for interleukin-10 (IL-10) on the efficacy of immunosuppressive therapy in patients after kidney transplantation

Anna Bogacz, Anna Polaszewska,Joanna Bartkowiak-Wieczorek,Karol Tejchman,Krzysztof Dziewanowski,Marek Ostrowski,Bogusław Czerny,Edmund Grześkowiak,Magdalena Sieńko,Bogusław Machaliński,Jerzy Sieńko,Maciej Kotowski

International Immunopharmacology（2020）

引用 8|浏览17

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摘要

•The correlation between tacrolimus dose and IL-10 genetic variations was examined.•The IL-10 −1082A > G polymorphism influenced tacrolimus intake dose.•The IL-10 −1082A > G polymorphism was not indicative of higher risk of acute renal transplant rejection.

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关键词

Renal transplantation,Immunosuppressive drugs,Tacrolimus,Polymorphism,Interleukin-10,Personalized therapy

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