The new organic nitrate 2-nitrate-1,3-diocthanoxypropan (NDOP) induces nitric oxide production and vasorelaxation via activation of inward-rectifier potassium channels (KIR)

Ricardo Bernardino-Paula,Alynne Carvalho-Galvão,Airlla L M Cavalcanti,Patrícia K L Rocha,Lucas R R A Carvalho,Maria C R Brandão,Petrônio F Athayde-Filho,Thiago F Diniz,Virginia S Lemos,Maria S França-Silva,Marcelo F Montenegro,Eddie Weitzberg,Jon O Lundberg,Mattias Carlström,Valdir A Braga

Nitric Oxide（2020）

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摘要

•NDOP donates NO via XOR mechanisms.•NDOP induces vasorelaxation by NO-cGMP-PKG pathway and modulation of K+ channels.•NDOP promotes hypotension and tachycardia in conscious rats.•NDOP presents low acute oral toxicity in female C57BL/6 mice.

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关键词

Organic nitrate,Nitric oxide donor,K+ channels,Xanthine oxireductase

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