Congenital syphilis: Missed opportunities and the case for rescreening during pregnancy and at delivery

•Two infants treated for syphilis born to at risk mothers who were not rescreened at delivery are described.•Screening for syphilis at the first prenatal visit is the standard of care but may fail to detect late term acquisition of maternal infection.•In high risk populations, rescreening for syphilis should be performed during pregnancy both early in the third trimester and again at delivery.•Early maternal syphilis may be recognized using the treponemal first reverse-screening algorithm.