Asymmetric Construction of Bispiro‐Cyclopropane‐Pyrazolones via a [2+1] Cyclization Reaction by Dipeptide‐Based Phosphonium Salt Catalysis
Advanced Synthesis and Catalysis(2020)
摘要
We reported herein an efficient alternative for asymmetric synthesis of structurally complicated chiral bispiro‐cyclopropane‐pyrazolones via dipeptide‐based phosphonium salt catalyzed [2+1] cyclization of 2,3‐dioxopyrrolidines and halogenated pyrazolones. With this catalytic asymmetric protocol, a broad range of bispiro heterocyclic compounds bearing a pyrazolone unit were prepared in high yields with excellent diastereo‐ and enatioselectivities. Of note, this transformation proceeds in a really short time under mild reaction conditions.
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关键词
dipeptide-based phosphonium salts,[2+1] cyclization,bispiro-cyclopropane-pyrazolones,asymmetric synthesis,hydrogen-bonding interaction
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