Copper‐Catalyzed Enantioselective Cyano(Fluoro)Alkylation of Alkenes
Advanced Synthesis and Catalysis(2020)
摘要
A copper‐catalyzed asymmetric cyano(fluoro)alkylation reaction of alkenes is reported. A range of chiral fluoroalkyl cyanides were obtained in high yields and excellent enantiomeric excess from readily available chemicals. The method uses fluoroalkyl iodides as the fluoroalkyl source and employs mild conditions. The peroxide LPO plays a significant role in promotion of this radical asymmetric reaction.
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关键词
Copper catalysis,Asymmetric cyanofluoroalkylation,Radical reaction,Difunctionalization of alkenes
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