Metal-to-Ligand Charge Transfer Chirality Sensing ofd-Glucose Assisted with GOX-Based Enzymatic Reaction

Chiral transition metal oxides nanoparticles (NPs) with tunable optical properties are widely accepted as promising toolbox for chiral recognition, stereoselective synthesis, and chiroptical devices. Herein, chirality-based strategy is presented for discrimination ofd-glucose from its enantiomer through a cooperative synergy between chiral cysteine capped MoO(2)NPs and the glucose oxidase nanosystem. The valence-state-dependent chirality induced by metal-ligand charge transfer effect is found to be ultrasensitive to its redox environment such as the presence of hydrogen peroxide, which is a key indicator of the stereoselective enzymatic reaction between glucose oxidase andd-glucose. With this know-how, glucose enantiomers can be precisely quantified with a limit of detection of 0.446 mu m. Such a chiral bio-nanosystem would be an ideal platform for a rational design of new types of biosensors, photocatalysts, and chirality-based nanodevices.